AustralieFrV1, Main, Exploration, bibRecord, 003B01

Confirmation of Childhood Acute Lymphoblastic Leukemia Variants, ARID5B and IKZF1, and Interaction with Parental Environmental Exposures

Identifieur interne : 003B01 ( Main/Exploration ); précédent : 003B00; suivant : 003B02

Confirmation of Childhood Acute Lymphoblastic Leukemia Variants, ARID5B and IKZF1, and Interaction with Parental Environmental Exposures

Auteurs : Tiffany-Jane Evans [Australie] ; Elizabeth Milne [Australie] ; Denise Anderson [Australie] ; Nicholas H. De Klerk [Australie] ; Sarra E. Jamieson [Australie] ; Bente A. Talseth-Palmer [Australie] ; Nikola A. Bowden [Australie] ; Elizabeth G. Holliday [Australie] ; Jérémie Rudant [France] ; Laurent Orsi [France] ; Ebony Richardson [Australie] ; Laura Lavis [Australie] ; Daniel Catchpoole [Australie] ; John R. Attia [Australie] ; Bruce K. Armstrong [Australie] ; Jacqueline Clavel [France] ; Rodney J. Scott [Australie]

Source :

PLoS ONE [ 1932-6203 ] ; 2014.

RBID : PMC:4195717

Descripteurs français

English descriptors

KwdEn :
- Adult, Child, DNA-Binding Proteins (genetics), Environmental Exposure, Female, Gene-Environment Interaction, Genome-Wide Association Study, Humans, Ikaros Transcription Factor (genetics), Male, Parents, Polymorphism, Single Nucleotide (genetics), Precursor Cell Lymphoblastic Leukemia-Lymphoma (genetics), Reproducibility of Results, Transcription Factors (genetics).
MESH :
- chemical , genetics : DNA-Binding Proteins, Ikaros Transcription Factor, Transcription Factors.
- genetics : Polymorphism, Single Nucleotide, Precursor Cell Lymphoblastic Leukemia-Lymphoma.
- Adult, Child, Environmental Exposure, Female, Gene-Environment Interaction, Genome-Wide Association Study, Humans, Male, Parents, Reproducibility of Results.

Abstract

Genome wide association studies (GWAS) have established association of ARID5B and IKZF1 variants with childhood acute lymphoblastic leukemia (ALL). Epidemiological studies suggest that environmental factors alone appear to make a relatively minor contribution to disease risk. The polygenic nature of childhood ALL predisposition together with the timing of environmental triggers may hold vital clues for disease etiology. This study presents results from an Australian GWAS of childhood ALL cases (n = 358) and population controls (n = 1192). Furthermore, we utilised family trio (n = 204) genotypes to extend our investigation to gene-environment interaction of significant loci with parental exposures before conception, and child’s sex and age. Thirteen SNPs achieved genome wide significance in the population based case/control analysis; ten annotated to ARID5B and three to IKZF1. The most significant SNPs in these regions were ARID5B rs4245595 (OR 1.63, CI 1.38–1.93, P = 2.13×10⁻⁹), and IKZF1 rs1110701 (OR 1.69, CI 1.42–2.02, p = 7.26×10⁻⁹). There was evidence of gene-environment interaction for risk genotype at IKZF1, whereby an apparently stronger genetic effect was observed if the mother took folic acid or if the father did not smoke prior to pregnancy (respective interaction P-values: 0.04, 0.05). There were no interactions of risk genotypes with age or sex (P-values >0.2). Our results evidence that interaction of genetic variants and environmental exposures may further alter risk of childhood ALL however, investigation in a larger population is required. If interaction of folic acid supplementation and IKZF1 variants holds, it may be useful to quantify folate levels prior to initiating use of folic acid supplements.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195717

DOI: 10.1371/journal.pone.0110255
PubMed: 25310577
PubMed Central: 4195717

Affiliations:

Australie, France

Le document en format XML

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<author><name sortKey="Jamieson, Sarra E" sort="Jamieson, Sarra E" uniqKey="Jamieson S" first="Sarra E." last="Jamieson">Sarra E. Jamieson</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Telethon Kids Institute, The University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Talseth Palmer, Bente A" sort="Talseth Palmer, Bente A" uniqKey="Talseth Palmer B" first="Bente A." last="Talseth-Palmer">Bente A. Talseth-Palmer</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bowden, Nikola A" sort="Bowden, Nikola A" uniqKey="Bowden N" first="Nikola A." last="Bowden">Nikola A. Bowden</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rudant, Jeremie" sort="Rudant, Jeremie" uniqKey="Rudant J" first="Jérémie" last="Rudant">Jérémie Rudant</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>INSERM, U1018, Department of Environmental Epidemiology of Cancers, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U1018, Department of Environmental Epidemiology of Cancers, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Paris-Sud University, UMR-S1018, Department of Environmental Epidemiology of Cancers, Research Center in Epidemiology and Population Health, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris-Sud University, UMR-S1018, Department of Environmental Epidemiology of Cancers, Research Center in Epidemiology and Population Health, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Orsi, Laurent" sort="Orsi, Laurent" uniqKey="Orsi L" first="Laurent" last="Orsi">Laurent Orsi</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>INSERM, U1018, Department of Environmental Epidemiology of Cancers, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U1018, Department of Environmental Epidemiology of Cancers, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Paris-Sud University, UMR-S1018, Department of Environmental Epidemiology of Cancers, Research Center in Epidemiology and Population Health, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris-Sud University, UMR-S1018, Department of Environmental Epidemiology of Cancers, Research Center in Epidemiology and Population Health, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>French National Registry of Childhood Blood Malignancies (RNHE), Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>French National Registry of Childhood Blood Malignancies (RNHE), Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Richardson, Ebony" sort="Richardson, Ebony" uniqKey="Richardson E" first="Ebony" last="Richardson">Ebony Richardson</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lavis, Laura" sort="Lavis, Laura" uniqKey="Lavis L" first="Laura" last="Lavis">Laura Lavis</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Catchpoole, Daniel" sort="Catchpoole, Daniel" uniqKey="Catchpoole D" first="Daniel" last="Catchpoole">Daniel Catchpoole</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>The Tumour Bank, The Children’s Cancer Research Unit, The Children’s Hospital Westmead, Westmead, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Tumour Bank, The Children’s Cancer Research Unit, The Children’s Hospital Westmead, Westmead, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Attia, John R" sort="Attia, John R" uniqKey="Attia J" first="John R." last="Attia">John R. Attia</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Department of Medicine, John Hunter Hospital and Hunter Medical Research Institute, New Lambton, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medicine, John Hunter Hospital and Hunter Medical Research Institute, New Lambton, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Armstrong, Bruce K" sort="Armstrong, Bruce K" uniqKey="Armstrong B" first="Bruce K." last="Armstrong">Bruce K. Armstrong</name>
<affiliation wicri:level="1"><nlm:aff id="aff10"><addr-line>School of Public Health, The University of Sydney and Sax Institute, Sydney, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Public Health, The University of Sydney and Sax Institute, Sydney, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>INSERM, U1018, Department of Environmental Epidemiology of Cancers, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U1018, Department of Environmental Epidemiology of Cancers, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Paris-Sud University, UMR-S1018, Department of Environmental Epidemiology of Cancers, Research Center in Epidemiology and Population Health, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris-Sud University, UMR-S1018, Department of Environmental Epidemiology of Cancers, Research Center in Epidemiology and Population Health, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>French National Registry of Childhood Blood Malignancies (RNHE), Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>French National Registry of Childhood Blood Malignancies (RNHE), Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff11"><addr-line>Molecular Genetics, Hunter Area Pathology Service, Newcastle, New South Wales, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Molecular Genetics, Hunter Area Pathology Service, Newcastle, New South Wales</wicri:regionArea>
<wicri:noRegion>New South Wales</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Child</term>
<term>DNA-Binding Proteins (genetics)</term>
<term>Environmental Exposure</term>
<term>Female</term>
<term>Gene-Environment Interaction</term>
<term>Genome-Wide Association Study</term>
<term>Humans</term>
<term>Ikaros Transcription Factor (genetics)</term>
<term>Male</term>
<term>Parents</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Precursor Cell Lymphoblastic Leukemia-Lymphoma (genetics)</term>
<term>Reproducibility of Results</term>
<term>Transcription Factors (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Enfant</term>
<term>Exposition environnementale</term>
<term>Facteur de transcription Ikaros (génétique)</term>
<term>Facteurs de transcription (génétique)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Interaction entre gènes et environnement</term>
<term>Leucémie-lymphome lymphoblastique à précurseurs B et T (génétique)</term>
<term>Mâle</term>
<term>Parents</term>
<term>Polymorphisme de nucléotide simple (génétique)</term>
<term>Protéines de liaison à l'ADN (génétique)</term>
<term>Reproductibilité des résultats</term>
<term>Étude d'association pangénomique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA-Binding Proteins</term>
<term>Ikaros Transcription Factor</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Polymorphism, Single Nucleotide</term>
<term>Precursor Cell Lymphoblastic Leukemia-Lymphoma</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de transcription Ikaros</term>
<term>Facteurs de transcription</term>
<term>Leucémie-lymphome lymphoblastique à précurseurs B et T</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Protéines de liaison à l'ADN</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Child</term>
<term>Environmental Exposure</term>
<term>Female</term>
<term>Gene-Environment Interaction</term>
<term>Genome-Wide Association Study</term>
<term>Humans</term>
<term>Male</term>
<term>Parents</term>
<term>Reproducibility of Results</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Enfant</term>
<term>Exposition environnementale</term>
<term>Femelle</term>
<term>Humains</term>
<term>Interaction entre gènes et environnement</term>
<term>Mâle</term>
<term>Parents</term>
<term>Reproductibilité des résultats</term>
<term>Étude d'association pangénomique</term>
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<front><div type="abstract" xml:lang="en"><p>Genome wide association studies (GWAS) have established association of <italic>ARID5B</italic>
 and <italic>IKZF1</italic>
 variants with childhood acute lymphoblastic leukemia (ALL). Epidemiological studies suggest that environmental factors alone appear to make a relatively minor contribution to disease risk. The polygenic nature of childhood ALL predisposition together with the timing of environmental triggers may hold vital clues for disease etiology. This study presents results from an Australian GWAS of childhood ALL cases (n = 358) and population controls (n = 1192). Furthermore, we utilised family trio (n = 204) genotypes to extend our investigation to gene-environment interaction of significant loci with parental exposures before conception, and child’s sex and age. Thirteen SNPs achieved genome wide significance in the population based case/control analysis; ten annotated to <italic>ARID5B</italic>
 and three to <italic>IKZF1</italic>
. The most significant SNPs in these regions were <italic>ARID5B</italic>
 rs4245595 (OR 1.63, CI 1.38–1.93, <italic>P</italic>
 = 2.13×10<sup>−9</sup>
), and <italic>IKZF1</italic>
 rs1110701 (OR 1.69, CI 1.42–2.02, p = 7.26×10<sup>−9</sup>
). There was evidence of gene-environment interaction for risk genotype at <italic>IKZF1</italic>
, whereby an apparently stronger genetic effect was observed if the mother took folic acid or if the father did not smoke prior to pregnancy (respective interaction P-values: 0.04, 0.05). There were no interactions of risk genotypes with age or sex (P-values >0.2). Our results evidence that interaction of genetic variants and environmental exposures may further alter risk of childhood ALL however, investigation in a larger population is required. If interaction of folic acid supplementation and <italic>IKZF1</italic>
 variants holds, it may be useful to quantify folate levels prior to initiating use of folic acid supplements.</p>
</div>
</front>
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<author><name sortKey="Davies, Sm" uniqKey="Davies S">SM Davies</name>
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Serveur d'exploration sur les relations entre la France et l'Australie

Confirmation of Childhood Acute Lymphoblastic Leukemia Variants, ARID5B and IKZF1, and Interaction with Parental Environmental Exposures

Confirmation of Childhood Acute Lymphoblastic Leukemia Variants, ARID5B and IKZF1, and Interaction with Parental Environmental Exposures

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	Serveur d'exploration sur les relations entre la France et l'Australie
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